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With breakfast. Paroxetine is an agent in a newer class of antidepressant medication known as selective serotonin reuptake inhibitors, may bring relief. Paxil should be taken once a day, either in the morning or evening, with or without food. Even if you begin to feel better, it is important to take Paxil, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. If you stop taking Paxil suddenly.

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